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Article

Serrated route to colorectal cancer: back street or super highway?

1 Jan 2001

Abstract excerpt

Morphological and molecular studies are beginning to distinguish separate evolutionary pathways for colorectal cancer. The serrated pathway encompassing hyperplastic aberrant crypt foci, hyperplastic polyps, mixed polyps, and serrated adenoma is increasingly being linked with genetic alterations, including DNA methylation, DNA microsatellite instability, K-ras mutation, and loss of chromosome 1p. The importance...

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Share to Colorectal Cancer Screening and Detection
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PMID: 11241405
DOI: 10.1002/1096-9896(200103)193:3<283::aid-path799>3.0.co;2-9

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