Article
Genetic variation in the tumor necrosis factor-alpha promoter region and in the stress protein hsp70-2: susceptibility and prognostic implications in breast carcinoma.
Cancer - 15 Feb 2001
Mestiri S, Bouaouina N, Ahmed S B, Khedhaier A, Jrad B B, Remadi S, Chouchane L
Abstract excerpt
BACKGROUND: Tumor necrosis factor-alpha (TNF-alpha) and stress proteins (heat shock proteins) are determining factors in the immune response to tumor cells. The authors designated a large study to investigate the susceptibility and prognostic implications of the genetic variation in TNF-alpha and hsp70-2 in breast carcinoma. METHODS: The authors used the polymerase chain reaction and restriction enzyme digestion...
Topics
- Adult
- Breast Neoplasms
- Breast Neoplasms, Male
- Female
- Genotype
- HSP70 Heat-Shock Proteins
- Humans
- Male
- Middle Aged
- Multivariate Analysis
- Polymorphism, Genetic
- Prognosis
- Risk Factors
- Survival Analysis