Article
Genetic variation in the stress protein hsp70-2 gene is highly associated with obesity.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity - 1 Apr 2001
Chouchane L, Danguir J, Beji C, Bouassida K, Camoin L, Sfar H, Gabbouj S, Strosberg A D
Abstract excerpt
BACKGROUND: Tumor necrosis factor-alpha (TNF-alpha) expression is increased in adipose tissue of both rodent models of obesity and obese humans. It has therefore been considered as a candidate gene for obesity. Several studies have indeed shown statistical evidence of linkage between obesity and the chromosomal region encompassing the TNF-alpha gene, suggesting that TNF-alpha and/or a nearby gene (eg hsp70 gene)...
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