Article
Genetic variation in IL-8 associated with increased risk and poor prognosis of breast carcinoma.
Human immunology - 1 Jan 2000
Snoussi Kaouther, Mahfoudh Wijden, Bouaouina Noureddine, Ahmed Slim Ben, Helal A Noureddine, Chouchane Lotfi
Abstract excerpt
Interleukin-8 (IL-8), a potent chemoattractant, has been demonstrated to contribute to human cancer progression through its potential functions as a mitogenic, angiogenic, and motogenic factor. We designed a broad study to investigate whether genetic variation in IL-8 has implications for susceptibility to and prognosis in breast carcinoma. We used the allele-specific polymerase chain reaction to characterize the...
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