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Article

Combined effects of IL-8 and CXCR2 gene polymorphisms on breast cancer susceptibility and aggressiveness.

BMC cancer - 12 Jun 2010

Snoussi Kaouther, Mahfoudh Wijden, Bouaouina Noureddine, Fekih Meriem, Khairi Hedi, Helal Ahmed N, Chouchane Lotfi

Abstract excerpt

BACKGROUND: Interleukin-8 (IL-8/CXCL-8) is a prototype of the ELR+CXC chemokines that play an important role in the promotion and progression of many human cancers including breast cancer. We have recently showed the implication of polymorphism (-251) T/A of IL-8 gene in the susceptibility and prognosis of breast carcinoma. IL-8 acts through its CXCR1 and CXCR2 receptors. CXCR2, expressed on the endothelial...

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Source

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Identifiers

PMID: 20540789
DOI: 10.1186/1471-2407-10-283
PMCID: PMC2895614

Genes

CXCR2
CXCR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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