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Article

Cell-transforming activity and mutagenicity of 5 phytoestrogens in cultured mammalian cells.

International journal of cancer - 20 Jun 2003

Tsutsui Takeki, Tamura Yukiko, Yagi Eiichi, Someya Hitomi, Hori Itsuro, Metzler Manfred, Barrett J Carl

Abstract excerpt

For the simultaneous assessment of in vitro carcinogenicity and mutagenicity of phytoestrogens, the abilities of 5 phytoestrogens, daidzein, genistein, biochanin A, prunetin, and coumestrol, to induce cell transformation and genetic effects were examined using the Syrian hamster embryo (SHE) cell model. Cellular growth was inhibited by all phytoestrogens in a concentration-related manner. The growth inhibitory...

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Identifiers

PMID: 12704663
DOI: 10.1002/ijc.11046

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SHE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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