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Article

Base excision repair of oxidative DNA damage activated by XPG protein.

Molecular cell - 1 Jan 1999

Klungland A, Höss M, Gunz D, Constantinou A, Clarkson S G, Doetsch P W, Bolton P H, Wood R D, Lindahl T

Abstract excerpt

Oxidized pyrimidines in DNA are removed by a distinct base excision repair pathway initiated by the DNA glycosylase--AP lyase hNth1 in human cells. We have reconstituted this single-residue replacement pathway with recombinant proteins, including the AP endonuclease HAP1/APE, DNA polymerase beta,...

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Source

Identifiers

PMID: 10024877
DOI: 10.1016/s1097-2765(00)80172-0

Genes

HAP1
XRCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-10024877-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Base excision repair of oxidative DNA damage activated by XPG protein.PMID 10024877Read ↗

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Major oxidative products of cytosine are substrates for the nucleotide incision repair pathway.Semantic proximity Read ↗

The Non-catalytic Function of XPG Protein during Dual Incision in Human Nucleotide Excision RepairSemantic proximity Read ↗

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