Article
Dach1 mutant mice bear no gross abnormalities in eye, limb, and brain development and exhibit postnatal lethality.
Molecular and cellular biology - 1 Mar 2001
Davis R J, Shen W, Sandler Y I, Amoui M, Purcell P, Maas R, Ou C N, Vogel H, Beaudet A L, Mardon G
Abstract excerpt
Drosophila dachshund is necessary and sufficient for compound eye development and is required for normal leg and brain development. A mouse homologue of dachshund, Dach1, is expressed in the developing retina and limbs, suggesting functional conservation of this gene. We have generated a loss-of-function mutation in Dach1 that results in the abrogation of the wild-type RNA and protein expression pattern in...
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