Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Saccharomyces cerevisiae MUM2 gene interacts with the DNA replication machinery and is required for meiotic levels of double strand breaks.

Genetics - 1 Mar 2001

Davis L, Barbera M, McDonnell A, McIntyre K, Sternglanz R, Jin Q, Loidl J, Engebrecht J

Abstract excerpt

The Saccharomyces cerevisiae MUM2 gene is essential for meiotic, but not mitotic, DNA replication and thus sporulation. Genetic interactions between MUM2 and a component of the origin recognition complex and polymerase alpha-primase suggest that MUM2 influences the function of the DNA replication machinery. Early meiotic gene expression is induced to a much greater extent in mum2 cells than in meiotic cells...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blotting, Southern
Share to Cell Cycle Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Damage

Share to DNA Replication

Share to Flow Cytometry

Share to In Situ Hybridization, Fluorescence

Share to Meiosis

Source

Open in PubMed Open full text

Identifiers

PMID: 11238403
DOI: 10.1093/genetics/157.3.1179
PMCID: PMC1461570

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Saccharomyces cerevisiae MUM2 gene interacts with the DNA replication machinery and is required for meiotic levels of double strand breaks.PMID 11238403Read ↗

The yeast MER2 gene is required for chromosome synapsis and the initiation of meiotic recombination.Semantic proximity Read ↗

Yeast meiotic mutants proficient for the induction of ectopic recombination.Semantic proximity Read ↗

Mms22 preserves genomic integrity during DNA replication in Schizosaccharomyces pombe.Semantic proximity Read ↗

Mutations in the MRE11, RAD50, XRS2, and MRE2 genes alter chromatin configuration at meiotic DNA double-stranded break sites in premeiotic and meiotic cells.Semantic proximity Read ↗

Molecular cloning and tissue-specific expression of the mutator2 gene (mu2) in Drosophila melanogaster.Semantic proximity Read ↗

Schizosaccharomyces pombe Mms1 channels repair of perturbed replication into Rhp51 independent homologous recombination.Semantic proximity Read ↗

The meiosis-specific Hop2 protein of S. cerevisiae ensures synapsis between homologous chromosomes.Semantic proximity Read ↗

A role for the MutL homologue MLH2 in controlling heteroduplex formation and in regulating between two different crossover pathways in budding yeast.Semantic proximity Read ↗

Saccharomyces cerevisiae checkpoint genes MEC1, RAD17 and RAD24 are required for normal meiotic recombination partner choice.Semantic proximity Read ↗

The Mnd1 protein forms a complex with hop2 to promote homologous chromosome pairing and meiotic double-strand break repair.Semantic proximity Read ↗

MIF2 is required for mitotic spindle integrity during anaphase spindle elongation in Saccharomyces cerevisiae.Semantic proximity Read ↗

Heteroduplex DNA formation and homolog pairing in yeast meiotic mutants.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.