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Article

Common genetic variation in ABCA1 is associated with altered lipoprotein levels and a modified risk for coronary artery disease.

Circulation - 6 Mar 2001

Clee S M, Zwinderman A H, Engert J C, Zwarts K Y, Molhuizen H O, Roomp K, Jukema J W, van Wijland M, van Dam M, Hudson T J, Brooks-Wilson A, Genest J, Kastelein J J, Hayden M R

Abstract excerpt

BACKGROUND: Low plasma HDL cholesterol (HDL-C) is associated with an increased risk of coronary artery disease (CAD). We recently identified the ATP-binding cassette transporter 1 (ABCA1) as the major gene underlying the HDL deficiency associated with reduced cholesterol efflux. Mutations within...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11238261
DOI: 10.1161/01.cir.103.9.1198

Genes

ABCA1
CAD

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11238261-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Common genetic variation in ABCA1 is associated with altered lipoprotein levels and a modified risk for coronary artery disease.PMID 11238261Read ↗

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Common gene polymorphism in ATP-binding cassette transporter A1 and coronary artery disease: A genetic association study and a structural analysis.Semantic proximity Read ↗

Common variants in the ATP-binding cassette transporter 1 gene with decreased HDL-cholesterol levels and coronary artery disease.Semantic proximity Read ↗

ABCA1 regulatory variants influence coronary artery disease independent of effects on plasma lipid levels.Semantic proximity Read ↗

Genotypic variation in ATP-binding cassette transporter-1 (ABCA1) as contributors to the high and low high-density lipoprotein-cholesterol (HDL-C) phenotype.Semantic proximity Read ↗

Genetic variation in ABCA1 predicts ischemic heart disease in the general population.Semantic proximity Read ↗

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