Article
Structural and functional disruption of vascular smooth muscle cells in a transgenic mouse model of amyloid angiopathy.
The American journal of pathology - 1 Mar 2001
Christie R, Yamada M, Moskowitz M, Hyman B
Abstract excerpt
The deposition of amyloid Abeta peptide in the wall of cerebral vessels (cerebral amyloid angiopathy), can lead to weakness and rupture of the vessel wall, resulting in hemorrhagic stroke. The Tg2576 transgenic mouse line, overexpressing mutant amyloid precursor protein in an age-dependent manner, forms amyloid angiopathy morphologically similar to that seen in the human. We report here the structural and...
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