Article
Mixed-lineage kinase 3 regulates B-Raf through maintenance of the B-Raf/Raf-1 complex and inhibition by the NF2 tumor suppressor protein.
Proceedings of the National Academy of Sciences of the United States of America - 21 Mar 2006
Chadee Deborah N, Xu Dazhong, Hung Gene, Andalibi Ali, Lim David J, Luo Zhijun, Gutmann David H, Kyriakis John M
Abstract excerpt
The Ras --> Raf --> MEK1/2 --> extracellular signal-regulated kinase (ERK) mitogen-activated protein kinase (MAPK) pathway couples mitogenic signals to cell proliferation. B-Raf and Raf-1 function within an oligomer wherein they are regulated in part by mutual transactivation. The MAPK kinase kinase (MAP3K) mixed-lineage kinase 3 (MLK3) is required for mitogen activation of B-Raf and cell proliferation. Here we...
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