Article
RET signaling-induced SPHK1 gene expression plays a role in both GDNF-induced differentiation and MEN2-type oncogenesis.
Journal of neurochemistry - 1 Sept 2007
Murakami Masashi, Ichihara Masatoshi, Sobue Sayaka, Kikuchi Ryosuke, Ito Hiromi, Kimura Ami, Iwasaki Takashi, Takagi Akira, Kojima Tetsuhito, Takahashi Masahide, Suzuki Motoshi, Banno Yoshiko, Nozawa Yoshinori, Murate Takashi
Abstract excerpt
RET, the receptor of glial cell line-derived neurotrophic factor (GDNF) family ligands, is important for the development of kidney and peripheral neurons. GDNF promotes survival and differentiation of neurons. Mutation of RET leads to the constitutive signal activation causing papillary thyroid carcinoma and multiple endocrine neoplasia type 2 (MEN2). In this study, we report that GDNF/RET signaling up-regulates...
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