Article
A probability model for predicting BRCA1 and BRCA2 mutations in breast and breast-ovarian cancer families.
British journal of cancer - 2 Mar 2001
Vahteristo P, Eerola H, Tamminen A, Blomqvist C, Nevanlinna H
Abstract excerpt
Germline mutations in BRCA1 and BRCA2 genes predispose to hereditary breast and ovarian cancer. Our aim was to find associations between the clinical characteristics and positive mutation status in 148 breast cancer families in order to predict the probability of finding a BRCA mutation in a family. Several factors were associated with mutations in univariate analysis, whereas in multivariate analysis (logistic...
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