Article
MDR1 expression in poor-risk acute myeloid leukemia with partial or complete monosomy 7.
Leukemia - 1 Mar 2001
van den Heuvel-Eibrink M M, Wiemer E A, de Boevere M J, Slater R M, Smit E M, van Noesel M M, van der Holt B, Schoester M, Pieters R, Sonneveld P
Abstract excerpt
Expression of the multidrug resistance (MDR1) phenotype, encoded by the MDR1 gene, is an adverse prognostic factor for CR and survival in acute myeloid leukemia (AML). Other prognostic factors, such as specific cytogenetic abnormalities, have been identified in AML. We have investigated the expression of the MDR1 gene in untreated AML patients with monosomy 7 (n = 12), and partial deletions (n = 7) of the long...
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