Article

Monosomy 7/del(7q) Cause Sensitivity to Inhibitors of Nicotinamide Phosphoribosyltransferase in Acute Myeloid Leukemia

2023-04-15

Abstract excerpt

<h4>ABSTRACT</h4> Monosomy 7 and del(7q) (-7/-7q) are frequent chromosomal abnormalities detected in up to 10% of acute myeloid leukemia (AML) patients. Despite unfavorable treatment outcomes, no approved targeted therapies exist for patients with -7/-7q. Therefore, we aimed to identify novel therapeutic vulnerabilities in AML with -7/-7q. Through an analysis of data from ex vivo drug screens in 270 primary AML sa...

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Literature Corpus work: 5f6073e2-7e01-5879-b9a8-92dc04301b50
DOI: 10.1101/2023.04.08.23287765

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