Article
Denaturing high-performance liquid chromatography for mutation detection and genotyping.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2013
Fackenthal Donna Lee, Chen Pei Xian, Howe Ted, Das Soma
Abstract excerpt
Denaturing high-performance liquid chromatography (DHPLC) is an accurate and efficient screening technique used for detecting DNA sequence changes by heteroduplex analysis. It can also be used for genotyping of single nucleotide polymorphisms (SNPs). The high sensitivity of DHPLC has made this technique one of the most reliable approaches to mutation analysis and, therefore, used in various areas of genetics,...
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