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High-throughput functional profiling of the human fungal pathogen Candida albicans genome

29 Dec 2022

Abstract excerpt

Candida albicans is a major fungal pathogen of humans. Although its genome has been sequenced more than two decades ago, there are still over 4300 uncharacterized C. albicans genes. We previously generated an ORFeome as well as a collection of destination vectors to facilitate overexpression of C. albicans ORFs. Here, we report the construction of ∼2500 overexpression mutants and their evaluation by in vitro...

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PMID: 36587858
DOI: 10.1016/j.resmic.2022.104025

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