Article
Polymorphisms of the glucose transporter (GLUT1) gene are associated with diabetic nephropathy.
Kidney international - 1 Mar 2001
Hodgkinson A D, Millward B A, Demaine A G
Abstract excerpt
BACKGROUND: Diabetic nephropathy (DN) is a major cause of morbidity and mortality in patients with type 1 diabetes mellitus. Recent studies suggest that genetic factors, including polymorphisms in the flanking region of the aldose reductase gene (5'ALR2), play an important role in the pathogenesis of nephropathy. Glucose transporter (GLUT1) activity has been implicated in renal hypertrophy and extracellular...
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