Article
Minor effect of GLUT1 polymorphisms on susceptibility to diabetic nephropathy in type 1 diabetes.
Diabetes - 1 Jul 2002
Ng Daniel P K, Canani Luis, Araki Shin-ichi, Smiles Adam, Moczulski Dariusz, Warram James H, Krolewski Andrzej S
Abstract excerpt
Elevation of intracellular glucose in mesangial cells as mediated by GLUT1 may be important in initiating cellular mechanisms that cause diabetic nephropathy. To determine whether DNA sequence differences in GLUT1 confer susceptibility to this complication, single-nucleotide polymorphisms (SNPs) in this gene were examined using a large case-control study. SNPs examined included the known XbaI (intron 2) and...
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