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Article

Calcineurin is required for hyphal elongation during mating and haploid fruiting in Cryptococcus neoformans.

The EMBO journal - 1 Mar 2001

Cruz M C, Fox D S, Heitman J

Abstract excerpt

Cryptococcus neoformans is a fungal pathogen that causes meningitis in immunocompromised patients. Its growth is sensitive to the immunosuppressants FK506 and cyclosporin, which inhibit the Ca2+- calmodulin-activated protein phosphatase calcineurin. Calcineurin is required for growth at 37 degrees C and virulence of C.neoformans. We found that calcineurin is also required for mating. FK506 blocks mating of...

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Identifiers

PMID: 11230126
DOI: 10.1093/emboj/20.5.1020
PMCID: PMC145507

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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