Article

A Glycolysis–Calcineurin Regulatory Axis Orchestrates Titan Cell Formation in <i>Cryptococcus neoformans</i>

2025-09-02

Abstract excerpt

Cryptococcus neoformans is an opportunistic fungal pathogen that causes pulmonary infections and life-threatening meningoencephalitis in immunocompromised individuals. In addition to the polysaccharide capsule and melanin, titan cell formation is a key virulence trait that promotes immune evasion and disease progression. Despite the established role of titan cells in C. neoformans pathogenesis, the molecular mech...

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Literature Corpus work: e93ef515-8266-5124-a4cb-e3437447e7a4
DOI: 10.1101/2025.09.02.673682

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