Article
Mutations in the gene for methylenetetrahydrofolate reductase, homocysteine levels, and vitamin status in women with a history of preeclampsia.
American journal of obstetrics and gynecology - 1 Feb 2001
Lachmeijer A M, Arngrímsson R, Bastiaans E J, Pals G, ten Kate L P, de Vries J I, Kostense P J, Aarnoudse J G, Dekker G A
Abstract excerpt
OBJECTIVE: This study was undertaken to assess frequencies of the methylenetetrahydrofolate reductase gene mutations cytosine-to-thymine substitution at base 677 (C677T) and adenine-to-cytosine substitution at base 1298 (A1298C) and their interactions with homocysteine and vitamin levels among Dutch women with preeclampsia. STUDY DESIGN: Mutations were studied in the following 5 groups: 47 consecutive women with...
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