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Article

Differential activation of LFA-1 and Mac-1 ligand binding domains.

Biochemical and biophysical research communications - 11 Nov 2005

Walters Susannah E, Tang Ren-Hong, Cheng Ming, Tan Suet-Mien, Law S K Alex

Abstract excerpt

Nine integrin alpha subunits contain an 'inserted' or I-domain, known to involve in ligand binding. Mutation of an invariant isoleucine residue in the I-domains of alphaL and alphaM has previously been reported to activate LFA-1 and Mac-1, respectively. In this article, we report notable differences in the regulation of adhesion of these two integrins. We find that mutation of the isoleucine residue in the...

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Source

Identifiers

PMID: 16199219
DOI: 10.1016/j.bbrc.2005.08.269

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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