Article
A molecular variant of the APC gene at codon 1822: its association with diet, lifestyle, and risk of colon cancer.
Cancer research - 1 Feb 2001
Slattery M L, Samowitz W, Ballard L, Schaffer D, Leppert M, Potter J D
Abstract excerpt
The adenomatous polyposis coli (APC) gene is important in the etiology of colon cancer. Although germ-line mutations of this gene rarely occur in the population, less penetrant variants of the gene have been reported. One variant, producing an aspartate to valine change at codon 1822 (D1822V) [corrected] has been previously reported as having an allele frequency of 10%. The purpose of this study was to determine...
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