Article
Single nucleotide polymorphisms of the APC gene and colorectal cancer risk: a case-control study in Taiwan.
BMC cancer - 29 Mar 2006
Chen Shee-Ping, Tsai Shih-Tzu, Jao Shu-Wen, Huang Yen-Lun, Chao Yu-Chen, Chen Yi-Lin, Wu Chang-Chieh, Lin Shinn-Zong, Harn Horng-Jyh
Abstract excerpt
BACKGROUND: Colorectal cancer (CRC), which has become especially prevalent in developed countries, is currently the third highest cause of cancer mortality in Taiwan. Mutation of the adenomatous polyposis coli (APC) gene, a tumour suppressor, is thought to be an early event in colorectal tumourigenesis. To date, however, no large-scale screening for APC gene variants in Chinese subjects has been performed. The...
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