Article
An association study between two missense variations of the benzodiazepine receptor (peripheral) gene and schizophrenia in a Japanese sample.
Journal of neural transmission (Vienna, Austria : 1996) - 1 Jan 2000
Kurumaji A, Nomoto H, Yoshikawa T, Okubo Y, Toru M
Abstract excerpt
The benzodiazepine receptor (peripheral) (BZRP) mainly localized on glial cells plays a role in neurosteroid synthesis, and increases with glial proliferation. We have recently reported a significant decrease in the density of BZRP labeled by [3H] PK 11195 in the postmortem brain of chronic schizophrenics, suggesting that dysfunctions of the BZRP are involved in the pathophysiology of schizophrenia. We screened...
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