Article
Detection of ret homodimers in MEN 2A-associated pheochromocytomas.
Biochemical and biophysical research communications - 17 Jan 1996
Wada M, Asai N, Tsuzuki T, Maruyama S, Ohiwa M, Imai T, Funahashi H, Takagi H, Takahashi M
Abstract excerpt
Using transfection of NIH 3T3 cells, we have recently demonstrated that multiple endocrine neoplasia (MEN) 2A mutations activate the c-Ret protein by inducing its disulfide-linked homodimerization on the cell surface. To investigate whether the homodimers are present in original tumors, the expression of the c-Ret protein was analyzed in eight sporadic and two MEN 2A-associated pheochromocytomas, the latter two...
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