Article
Glycophosphatidylinositol-anchored protein deficiency as a marker of mutator phenotypes in cancer.
Cancer research - 15 Jan 2001
Chen R, Eshleman J R, Brodsky R A, Medof M E
Abstract excerpt
Phosphatidylinositol glycan-A (PIGA) is a gene that encodes an element required for the first step in glycosylphosphatidylinositol (GPI) anchor assembly. Because PIGA is X-located, a single mutation is sufficient to abolish cell surface GPI-anchored protein expression. In this study, we investigated whether mutation of the PIGA gene could be exploited to identify mutator (Mut) phenotypes in cancer. We examined...
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