Article
PIGA Mutations and Glycosylphosphatidylinositol Anchor Dysregulation in Polyposis-Associated Duodenal Tumorigenesis.
Molecular cancer research : MCR - 4 Jun 2024
Meuser Elena, Chang Kyle, Walters Angharad, Hurley Joanna J, West Hannah D, Perry Iain, Mort Matthew, Reyes-Uribe Laura, Truscott Rebekah, Jones Nicholas, Lawrence Rachel, Jenkins Gareth, Giles Peter, Dolwani Sunil, Al-Sarireh Bilal, Hawkes Neil, Short Emma, Williams Geraint T, Taggart Melissa W, Luetchford Kim, Lynch Patrick M, Terlouw Diantha, Nielsen Maartje, Walton Sarah-Jane, Latchford Andrew, Clark Susan K, Sampson Julian R, Vilar Eduardo, Thomas Laura E
Abstract excerpt
The pathogenesis of duodenal tumors in the inherited tumor syndromes familial adenomatous polyposis (FAP) and MUTYH-associated polyposis (MAP) is poorly understood. This study aimed to identify genes that are significantly mutated in these tumors and to explore the effects of these mutations. Whole exome and whole transcriptome sequencing identified recurrent somatic coding variants of phosphatidylinositol...
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