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Article

Identification of the intimin-binding domain of Tir of enteropathogenic Escherichia coli.

Cellular microbiology - 1 Jul 1999

de Grado M, Abe A, Gauthier A, Steele-Mortimer O, DeVinney R, Finlay B B

Abstract excerpt

Enteropathogenic Escherichia coli (EPEC) attaches intimately to mammalian cells via a bacterial outer membrane adhesion molecule, intimin, and its receptor in the host cell membrane, Tir. Tir is a bacterial protein translocated into the host cell membrane and tyrosine phosphorylated after insertion. Tir-intimin binding induces organized actin polymerization beneath the adherent bacteria, resulting in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 11207537
DOI: 10.1046/j.1462-5822.1999.00001.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Identification of the intimin-binding domain of Tir of enteropathogenic Escherichia coli.PMID 11207537Read ↗

Insertion of the enteropathogenic Escherichia coli Tir virulence protein into membranes in vitro.Semantic proximity Read ↗

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Characterization of TccP-mediated N-WASP activation during enterohaemorrhagic Escherichia coli infection.Semantic proximity Read ↗

Enteropathogenic Escherichia coli translocated intimin receptor, Tir, requires a specific chaperone for stable secretion.Semantic proximity Read ↗

Translocation of enterohemorrhagic Escherichia coli effector Tir to the plasma membrane via host Golgi apparatus.Semantic proximity Read ↗

Enteropathogenic Escherichia coli (EPEC) attachment to epithelial cells: exploiting the host cell cytoskeleton from the outsideSemantic proximity Read ↗

The enterohaemorrhagic Escherichia coli (serotype O157:H7) Tir molecule is not functionally interchangeable for its enteropathogenic E. coli (serotype O127:H6) homologueSemantic proximity Read ↗

Intimate host attachment: enteropathogenic and enterohaemorrhagic<i>Escherichia coli</i>Semantic proximity Read ↗

Crystal structure of EHEC intimin: insights into the complementarity between EPEC and EHEC.Semantic proximity Read ↗

Mechanical fractionation reveals structural requirements for enteropathogenic Escherichia coli Tir insertion into host membranes.Semantic proximity Read ↗

EspFU is a translocated EHEC effector that interacts with Tir and N-WASP and promotes Nck-independent actin assembly.Semantic proximity Read ↗

Intimin types alpha, beta, and gamma bind to nucleolin with equivalent affinity but lower avidity than to the translocated intimin receptor.Semantic proximity Read ↗

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