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Article

Intimin types alpha, beta, and gamma bind to nucleolin with equivalent affinity but lower avidity than to the translocated intimin receptor.

The Journal of biological chemistry - 6 Aug 2004

Sinclair James F, O'Brien Alison D

Abstract excerpt

The outer membrane adhesins of enteropathogenic Escherichia coli, Citrobacter rodentium, and enterohemorrhagic E. coli (EHEC) O157:H7 that mediate attach and efface intestinal lesions are classified as intimin alpha, beta, and gamma, respectively. Each of these intimin types binds to its cognate, bacterially encoded receptor (called Tir for translocated intimin receptor) to promote tight adherence of the organism...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15173179
DOI: 10.1074/jbc.M401616200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Intimin types alpha, beta, and gamma bind to nucleolin with equivalent affinity but lower avidity than to the translocated intimin receptor.PMID 15173179Read ↗

Identification of the intimin-binding domain of Tir of enteropathogenic Escherichia coli.Semantic proximity Read ↗

Crystal structure of EHEC intimin: insights into the complementarity between EPEC and EHEC.Semantic proximity Read ↗

Intimate host attachment: enteropathogenic and enterohaemorrhagic<i>Escherichia coli</i>Semantic proximity Read ↗

The Enteropathogenic E. coli (EPEC) Tir Effector Inhibits NF-κB Activity by Targeting TNFα Receptor-Associated FactorsSemantic proximity Read ↗

Enteropathogenic Escherichia coli (EPEC) attachment to epithelial cells: exploiting the host cell cytoskeleton from the outsideSemantic proximity Read ↗

Intimin type influences the site of human intestinal mucosal colonisation by enterohaemorrhagic Escherichia coli O157:H7.Semantic proximity Read ↗

Characterization of TccP-mediated N-WASP activation during enterohaemorrhagic Escherichia coli infection.Semantic proximity Read ↗

The enterohaemorrhagic Escherichia coli (serotype O157:H7) Tir molecule is not functionally interchangeable for its enteropathogenic E. coli (serotype O127:H6) homologueSemantic proximity Read ↗

FadA from Fusobacterium nucleatum Utilizes both Secreted and Nonsecreted Forms for Functional Oligomerization for Attachment and Invasion of Host CellsSemantic proximity Read ↗

Interaction of enteropathogenic and Shiga toxin-producing Escherichia coli and porcine intestinal mucosa: role of intimin and Tir in adherence.Semantic proximity Read ↗

GBP1 recruitment to actin-rich pedestals induced by extracellular Gram-negative bacteria promotes pyroptosisSemantic proximity Read ↗

Enteropathogenic E. coli (EPEC) transfers its receptor for intimate adherence into mammalian cells.Semantic proximity Read ↗

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