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Article

Enteropathogenic Escherichia coli translocated intimin receptor, Tir, requires a specific chaperone for stable secretion.

Molecular microbiology - 1 Sept 1999

Abe A, de Grado M, Pfuetzner R A, Sánchez-Sanmartín C, Devinney R, Puente J L, Strynadka N C, Finlay B B

Abstract excerpt

Enteropathogenic Escherichia coli (EPEC) secretes several Esps (E. coli-secreted proteins) that are required for full virulence. Insertion of the bacterial protein Tir into the host epithelial cell membrane is facilitated by a type III secretion apparatus, and at least EspA and EspB are required for Tir translocation. An EPEC outer membrane protein, intimin, interacts with Tir on the host membrane to establish...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10510231
DOI: 10.1046/j.1365-2958.1999.01558.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Enteropathogenic Escherichia coli translocated intimin receptor, Tir, requires a specific chaperone for stable secretion.PMID 10510231Read ↗

Identification of CesT, a chaperone for the type III secretion of Tir in enteropathogenic Escherichia coli.Semantic proximity Read ↗

CesT is a multi‐effector chaperone and recruitment factor required for the efficient type III secretion of both LEE‐ and non‐LEE‐encoded effectors of enteropathogenic Escherichia coliSemantic proximity Read ↗

CesAB is an enteropathogenic Escherichia coli chaperone for the type-III translocator proteins EspA and EspB.Semantic proximity Read ↗

EspB and EspD require a specific chaperone for proper secretion from enteropathogenic Escherichia coli.Semantic proximity Read ↗

Identification of the intimin-binding domain of Tir of enteropathogenic Escherichia coli.Semantic proximity Read ↗

Hierarchical delivery of an essential host colonization factor in enteropathogenic Escherichia coli.Semantic proximity Read ↗

Esp-independent functional integration of the translocated intimin receptor (Tir) of enteropathogenic Escherichia coli (EPEC) into host cell membranes.Semantic proximity Read ↗

Enterohaemorrhagic Escherichia coli Tir requires a C-terminal 12-residue peptide to initiate EspF-mediated actin assembly and harbours N-terminal sequences that influence pedestal length.Semantic proximity Read ↗

Characterization of TccP-mediated N-WASP activation during enterohaemorrhagic Escherichia coli infection.Semantic proximity Read ↗

A carboxy-terminal domain of Tir from enterohemorrhagic Escherichia coli O157:H7 (EHEC O157:H7) required for efficient type III secretion.Semantic proximity Read ↗

SepZ/EspZ Is Secreted and Translocated into HeLa Cells by the Enteropathogenic Escherichia coli Type III Secretion SystemSemantic proximity Read ↗

Translocation of enterohemorrhagic Escherichia coli effector Tir to the plasma membrane via host Golgi apparatus.Semantic proximity Read ↗

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