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Intimate host attachment: enteropathogenic and enterohaemorrhagic<i>Escherichia coli</i>

8 Aug 2013

Abstract excerpt

Enteropathogenic and enterohaemorrhagic Escherichia coli use a novel infection strategy to colonize the gut epithelium, involving translocation of their own receptor, Tir, via a type III secretion system and subsequent formation of attaching and effecting (A/E) lesions. Following integration into the host cell plasma membrane of cultured cells, and clustering by the outer membrane adhesin intimin, Tir triggers...

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PMID: 23927593
DOI: 10.1111/cmi.12179

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