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Article

Translocation of enterohemorrhagic Escherichia coli effector Tir to the plasma membrane via host Golgi apparatus.

Molecular medicine reports - 1 Aug 2017

Mao Chan, Gu Jiang, Wang Hai-Guang, Fang Yao, Yang Ping, Tang Bin, Li Na, Wang Ting-Ting, Zou Quan-Ming, Li Qian

Abstract excerpt

The translocated intimin receptor (Tir) is a canonical type III secretion system effector, secreted by the enterohemorrhagic Escherichia coli (E. coli). This receptor alters the regular cellular processing of host cells, to promote intracellular bacterial replication and evasion of the host immune system. Tir is translocated and integrated into the host cell plasma membrane, a process required for its pathogenic...

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Identifiers

PMID: 28627613
DOI: 10.3892/mmr.2017.6763

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Translocation of enterohemorrhagic Escherichia coli effector Tir to the plasma membrane via host Golgi apparatus.PMID 28627613Read ↗

Identification of the intimin-binding domain of Tir of enteropathogenic Escherichia coli.Semantic proximity Read ↗

Enteropathogenic Escherichia coli translocated intimin receptor, Tir, requires a specific chaperone for stable secretion.Semantic proximity Read ↗

A carboxy-terminal domain of Tir from enterohemorrhagic Escherichia coli O157:H7 (EHEC O157:H7) required for efficient type III secretion.Semantic proximity Read ↗

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Intimate host attachment: enteropathogenic and enterohaemorrhagic<i>Escherichia coli</i>Semantic proximity Read ↗

Exploitation of host cells by enteropathogenic <i>Escherichia</i> <i>coli</i>Semantic proximity Read ↗

Enterohaemorrhagic Escherichia coli Tir requires a C-terminal 12-residue peptide to initiate EspF-mediated actin assembly and harbours N-terminal sequences that influence pedestal length.Semantic proximity Read ↗

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Esp-independent functional integration of the translocated intimin receptor (Tir) of enteropathogenic Escherichia coli (EPEC) into host cell membranes.Semantic proximity Read ↗

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The enterohaemorrhagic Escherichia coli (serotype O157:H7) Tir molecule is not functionally interchangeable for its enteropathogenic E. coli (serotype O127:H6) homologueSemantic proximity Read ↗

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