Article
Ethnic variability in the allelic distribution of human aryl hydrocarbon receptor codon 554 and assessment of variant receptor function in vitro.
Pharmacogenetics - 1 Feb 2001
Wong J M, Harper P A, Meyer U A, Bock K W, Morike K, Lagueux J, Ayotte P, Tyndale R F, Sellers E M, Manchester D K, Okey A B
Abstract excerpt
The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcriptional regulator of several genes including the cytochrome P4501 (CYP1) family as well as genes encoding factors involved in cell growth and differentiation. In mice, several polymorphic forms of the AHR are known, some of which have altered affinity for toxic and carcinogenic ligands. Remarkably little genetic variation has been detected in the...
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