Article
Insertions, substitutions, and the origin of microsatellites.
Genetical research - 1 Dec 2000
Zhu Y, Strassmann J E, Queller D C
Abstract excerpt
This paper uses data from the Human Gene Mutation Database to contrast two hypotheses for the origin of short DNA repeats: substitutions and insertions that duplicate adjacent sequences. Because substitutions are much more common than insertions, they are the dominant source of new 2-repeat loci. Insertions are rarer, but over 70% of the 2-4 base insertion mutations are duplications of adjacent sequences, and...
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