Appearance of biomarkers of in vitro ageing after successive stimulation of WI‐38 fibroblasts with IL‐1α and TNF‐α: senescence associated β‐galactosidase activity and morphotype transition

Abstract excerpt

Sublethal oxidative stresses increase the proportions of human fibroblasts positive for senescence associated beta-galactosidase activity and accelerate the transition in the fibroblast morphotypes characterising fibroblast ageing. Stimulation of fibroblasts with TNF-alpha or IL-1alpha transiently increases the production of reactive oxygen species (ROS) in human fibroblasts. Here we propose that repeated...

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