Human dermal fibroblast senescence in response to single and recurring oxidative stress

Abstract excerpt

Introduction: Aging results in an accumulation of damaged cells, which reduces the health of tissues and their regenerative capabilities. In the skin, there are both internal and external drivers of oxidative stress that result in aging phenotypes. Oxidative stress has been used to model senescence in vitro ; however, there has been a lack of research determining whether the severity of oxidative stress...

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