Article
The interferon gene cluster: a candidate region for MS predisposition? Multiple Sclerosis Study Group.
Genes and immunity - 1 Sept 1999
Miterski B, Jaeckel S, Epplen J T, Pöhlau D, Hardt C
Abstract excerpt
The clinical benefits of interferon (IFN) beta therapy in some multiple sclerosis (MS) patients are still unexplained, raising the question whether polymorphism within the IFNB gene itself would provide an explanation. Screening the IFNB gene by single strand conformation polymorphism (SSCP) analysis and sequencing, a single nucleotide polymorphism was identified. Both alleles were distributed with similar...
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