Article
Pharmacogenetic study of long-term response to interferon-β treatment in multiple sclerosis.
The pharmacogenomics journal - 1 Jan 2017
Clarelli F, Liberatore G, Sorosina M, Osiceanu A M, Esposito F, Mascia E, Santoro S, Pavan G, Colombo B, Moiola L, Martinelli V, Comi G, Martinelli-Boneschi F
Abstract excerpt
The aim of the study is the identification of genetic factors that influence the long-term response to interferon-β (IFNβ) (4-year follow-up). We performed a genome-wide association study in 337 IFNβ-treated Italian multiple sclerosis patients at the extreme of treatment response, and we meta-analyzed association effects, integrating results with pathway analysis, gene-expression profiling of IFNβ-stimulated...
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