Article
Genes and (auto)immunity in primary biliary cirrhosis.
Genes and immunity - 1 Oct 2005
Selmi C, Invernizzi P, Zuin M, Podda M, Seldin M F, Gershwin M E
Abstract excerpt
Primary biliary cirrhosis (PBC) is a chronic autoimmune cholestatic liver disease most commonly encountered in postmenopausal women; it is characterized by high-titer serum autoantibodies to mitochondrial antigens, elevated serum IgM, progressive destruction of intrahepatic bile ducts, and ultimately liver cirrhosis and failure. The cytopathic mechanisms leading to the selective destruction of intrahepatic...
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