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Article

Glypican-3 (GPC3) expression in human placenta: localization to the differentiated syncytiotrophoblast.

1 Jan 2001

Abstract excerpt

The expression of glypican-3 (GPC3), a heparan-sulfate proteoglycan associated with the Simpson-Golabi-Behmel fetal overgrowth syndrome, was studied in normal human placental tissue and cell lines derived from human placentae. Cytotrophoblasts derived from term placentae expressed GPC3 mRNA at low levels in culture. GPC3 mRNA expression increased markedly during trophoblast differentiation. By contrast,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Identifiers

PMID: 11193214
DOI: 10.14670/hh-16.71

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Glypican-3 (GPC3) expression in human placenta: localization to the differentiated syncytiotrophoblast.PMID 11193214Read ↗

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Mutational analysis of the GPC3/GPC4 glypican gene cluster on Xq26 in patients with Simpson-Golabi-Behmel syndrome: identification of loss-of-function mutations in the GPC3 gene.Semantic proximity Read ↗

Role of Glycanation and Convertase Maturation of Soluble Glypican-3 in Inhibiting Proliferation of Hepatocellular Carcinoma Cells.Semantic proximity Read ↗

Transcriptional Regulation of the Human Chorionic Gonadotropin β Gene during Villous Trophoblast DifferentiationSemantic proximity Read ↗

Simpson-Golabi-Behmel syndrome type 1 and hepatoblastoma in a patient with a novel exon 2-4 duplication of the GPC3 gene.Semantic proximity Read ↗

Multiple Sp1 sites efficiently drive transcription of the TATA-less promoter of the human glypican 3 (GPC3) gene.Semantic proximity Read ↗

Characterization of cDNA encoding novel pregnancy-specific glycoprotein variants.Semantic proximity Read ↗

Gpc3 expression correlates with the phenotype of the Simpson-Golabi-Behmel syndrome.Semantic proximity Read ↗

Processing by convertases is not required for glypican-3-induced stimulation of hepatocellular carcinoma growth.Semantic proximity Read ↗

The Simpson-Golabi-Behmel gene, GPC3, is not involved in sporadic Wilms tumorigenesis.Semantic proximity Read ↗

OCI-5/GPC3, a Glypican Encoded by a Gene That Is Mutated in the Simpson-Golabi-Behmel Overgrowth Syndrome, Induces Apoptosis in a Cell Line–specific MannerSemantic proximity Read ↗

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