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Expression of glypican 3(GPC3) in embryonal tumors

1 Jan 2000

Abstract excerpt

Embryonal tumors, such as neuroblastoma, medulloblastoma and Wilms' tumor, have their peak incidence in the first 4 years of life. These neoplasias exhibit genetic and clinical heterogeneity, but little is known about their molecular pathogenesis. Application of the differential-display PCR approach led to the identification of a gene, glypican 3 (GPC3), that is differentially expressed in cancer cells....

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PMID: 11008203
DOI: 10.1002/1097-0215(20000920)89:5<418::aid-ijc4>3.0.co;2-i

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