Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Processing by convertases is not required for glypican-3-induced stimulation of hepatocellular carcinoma growth.

The Journal of biological chemistry - 16 Dec 2005

Capurro Mariana I, Shi Wen, Sandal Shaifali, Filmus Jorge

Abstract excerpt

Glypicans are a family of heparan sulfate proteoglycans that are bound to the cell surface by a lipid anchor. Six members of this family have been identified in mammals (GPC1-GPC6). Glypicans act as regulators of the activity of various cytokines, including Wnts, Hedgehogs, and bone morphogenetic proteins. It has been reported that processing by a convertase is required for GPC3 activity during convergent...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aspartic Acid Endopeptidases
Share to Culture Media, Conditioned

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glypicans

Share to Heparan Sulfate Proteoglycans

Share to Immunoprecipitation

Share to Luciferases

Share to Wnt-5a Protein

Share to Wnt Proteins

Source

Identifiers

PMID: 16227623
DOI: 10.1074/jbc.M507004200

Genes

GPC3
GPC1
GPC6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Processing by convertases is not required for glypican-3-induced stimulation of hepatocellular carcinoma growth.PMID 16227623Read ↗

Role of Glycanation and Convertase Maturation of Soluble Glypican-3 in Inhibiting Proliferation of Hepatocellular Carcinoma Cells.Semantic proximity Read ↗

Biology and function of glypican-3 as a candidate for early cancerous transformation of hepatocytes in hepatocellular carcinomaSemantic proximity Read ↗

Structural and Functional Impact of Posttranslational Modification of Glypican-3 on Liver CarcinogenesisSemantic proximity Read ↗

Soluble glypican 3 inhibits the growth of hepatocellular carcinoma in vitro and in vivo.Semantic proximity Read ↗

Silencing of the glypican-3 gene affects the biological behavior of human hepatocellular carcinoma cellsSemantic proximity Read ↗

The contribution of in vivo manipulation of gene expression to the understanding of the function of glypicans.Semantic proximity Read ↗

Glypican-3-mediated oncogenesis involves the Insulin-like growth factor-signaling pathwaySemantic proximity Read ↗

Simpson-Golabi-Behmel syndrome type 1 and hepatoblastoma in a patient with a novel exon 2-4 duplication of the GPC3 gene.Semantic proximity Read ↗

G<sub>4</sub>Mab-9: An Anti-Glypican-4 Monoclonal Antibody for Multiple ApplicationsSemantic proximity Read ↗

Fine-tuning of cell signaling by glypicans.Semantic proximity Read ↗

The oncofetal gene glypican 3 is regulated in the postnatal liver by zinc fingers and homeoboxes 2 and in the regenerating liver by alpha-fetoprotein regulator 2Semantic proximity Read ↗

A patient with Simpson-Golabi-Behmel syndrome, biliary cirrhosis and successful liver transplantation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.