Article
Gpc3 expression correlates with the phenotype of the Simpson-Golabi-Behmel syndrome.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Dec 1998
Pellegrini M, Pilia G, Pantano S, Lucchini F, Uda M, Fumi M, Cao A, Schlessinger D, Forabosco A
Abstract excerpt
Interest in glypican-3 (GPC3), a member of the glypican-related integral membrane heparan sulfate proteoglycans (GRIPS) family, has increased with the finding that it is mutated in the Simpson-Golabi-Behmel overgrowth syndrome (Pilia et al. [1996] Nat. Genet. 12:241-247). The working model sugges...
Topics
- Abnormalities, Multiple
- Animals
- Blotting, Northern
- Ectoderm
- Gene Expression Regulation, Developmental
- Gigantism
- Glypicans
- Heparan Sulfate Proteoglycans
- Heparitin Sulfate
- Humans
- In Situ Hybridization
- Mesoderm
- Mice
- Phenotype
- Proteoglycans
- Syndrome