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Article

Gpc3 expression correlates with the phenotype of the Simpson-Golabi-Behmel syndrome.

Developmental dynamics : an official publication of the American Association of Anatomists - 1 Dec 1998

Pellegrini M, Pilia G, Pantano S, Lucchini F, Uda M, Fumi M, Cao A, Schlessinger D, Forabosco A

Abstract excerpt

Interest in glypican-3 (GPC3), a member of the glypican-related integral membrane heparan sulfate proteoglycans (GRIPS) family, has increased with the finding that it is mutated in the Simpson-Golabi-Behmel overgrowth syndrome (Pilia et al. [1996] Nat. Genet. 12:241-247). The working model suggested that the membrane-bound protein acts locally to limit tissue and organ growth and that it may function by...

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Source

Identifiers

PMID: 9853964
DOI: 10.1002/(SICI)1097-0177(199812)213:4<431::AID-AJA8>3.0.CO;2-7

Genes

GPC3
IGF2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Gpc3 expression correlates with the phenotype of the Simpson-Golabi-Behmel syndrome.PMID 9853964Read ↗

Glypican-3-deficient mice exhibit developmental overgrowth and some of the abnormalities typical of Simpson-Golabi-Behmel syndrome.Semantic proximity Read ↗

Simpson Golabi Behmel syndrome: progress toward understanding the molecular basis for overgrowth, malformation, and cancer predisposition.Semantic proximity Read ↗

GPC3 mutation analysis in a spectrum of patients with overgrowth expands the phenotype of Simpson-Golabi-Behmel syndrome.Semantic proximity Read ↗

Genotype/phenotype correlations of males affected by Simpson-Golabi-Behmel syndrome with GPC3 gene mutations: patient report and review of the literature.Semantic proximity Read ↗

Expression of glypican 3(GPC3) in embryonal tumorsSemantic proximity Read ↗

Biology and function of glypican-3 as a candidate for early cancerous transformation of hepatocytes in hepatocellular carcinomaSemantic proximity Read ↗

Molecular analysis of a novel intragenic deletion in GPC3 in three cousins with Simpson-Golabi-Behmel syndrome.Semantic proximity Read ↗

Simpson-Golabi-Behmel syndrome type 1 and hepatoblastoma in a patient with a novel exon 2-4 duplication of the GPC3 gene.Semantic proximity Read ↗

Glypican-3-mediated oncogenesis involves the Insulin-like growth factor-signaling pathwaySemantic proximity Read ↗

Regulatory variation at glypican-3 underlies a major growth QTL in mice.Semantic proximity Read ↗

A patient with Simpson-Golabi-Behmel syndrome, biliary cirrhosis and successful liver transplantation.Semantic proximity Read ↗

Mutational analysis of the GPC3/GPC4 glypican gene cluster on Xq26 in patients with Simpson-Golabi-Behmel syndrome: identification of loss-of-function mutations in the GPC3 gene.Semantic proximity Read ↗

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