Article
M184V is associated with a low incidence of thymidine analogue mutations and low phenotypic resistance to zidovudine and stavudine.
AIDS (London, England) - 16 Aug 2002
Ait-Khaled Mounir, Stone Chris, Amphlett Gillian, Clotet Bonaventura, Staszewski Schlomo, Katlama Christine, Tisdale Margaret
Abstract excerpt
The resistance of HIV clinical isolates with or without M184V was analysed in relation to plasma HIV-1-RNA level and time on therapy. The number of thymidine analogue mutations (TAMs) was lower in isolates with M184V, this was independent of plasma HIV-1-RNA level and time on therapy for T215F/Y, D67N and L210W. This suggests a direct effect of M184V on the reduced selection of TAMs. Lamivudine use was...
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