Article
Risk factors for selection of the L74I reverse transcriptase mutation in human immunodeficiency virus type 1-infected patients.
Antimicrobial agents and chemotherapy - 1 Jul 2006
Wirden Marc, Roquebert Bénédicte, Derache Anne, Simon Anne, Duvivier Claudine, Ghosn Jade, Dominguez Stephanie, Boutonnet Véronique, Ait-Arkoub Zaina, Katlama Christine, Calvez Vincent, Marcelin Anne-Genevieve
Abstract excerpt
We analyzed 3,475 human immunodeficiency virus sequences and 241 therapeutic histories. The L74I mutation was carried by 7% of viruses. L74I was strongly associated with T215F, K70R, and V75M/S/T/A mutations and increased with the number of thymidine analog mutations. It seemed to be linked to the use of abacavir or efavirenz.
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