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Article

Effect of isolated V118I mutation in reverse transcriptase on response to first-line antiretroviral therapy.

AIDS (London, England) - 30 Jan 2008

Mihailidis Christos, Dunn David, Pillay Deenan, Pozniak Anton

Abstract excerpt

Although the V118I mutation in reverse transcriptase causes a reduced incorporation of zidovudine and lamivudine into transcribed viral DNA, it also decreases ATP-mediated pyrophosphorylysis. In this manner, its overall impact on enzymatic activity appears to be neutral when assessed in vitro. Nevertheless, V118I remains identified as a resistance mutation by a number of commonly utilised resistance mutation...

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Source

Identifiers

PMID: 18195570
DOI: 10.1097/QAD.0b013e3282f3744f

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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