Article
Polymorphism of the human immunodeficiency virus type 1 (HIV-1) protease gene and response of HIV-1-infected patients to a protease inhibitor.
Journal of clinical microbiology - 1 Sept 1999
Bossi P, Mouroux M, Yvon A, Bricaire F, Agut H, Huraux J M, Katlama C, Calvez V
Abstract excerpt
In order to analyze the impact of protease gene polymorphism on response to regimens containing a protease inhibitor, the entire protease coding domain from 58 human immunodeficiency virus type 1 (HIV-1)-infected patients who were protease inhibitor naive was sequenced before therapy was started. Plasma HIV-1 RNA levels were measured at baseline and at month 3 and month 6 after treatment. All patients were...
Topics
- Acquired Immunodeficiency Syndrome
- HIV Protease
- HIV Protease Inhibitors
- HIV-1
- Humans
- Mutation
- Polymorphism, Genetic
- RNA, Viral